SEPTEMBER 9, 2016

AYER, Mass.–Cambrooke Therapeutics Inc., a leader in therapeutic nutrition for inborn errors of metabolism and ketogenic diet therapy, announces the launches of Glytactin RESTORE Powder™ and Glytactin RESTORE Lite Powder™, two medical food hydration beverages offered in convenient, portable, single-serve, stick-packs for the dietary management of Phenylketonuria (PKU).

Glytactin with GMP is made from a natural whole protein derived from whey called glycomacropeptide (GMP). Published clinical evidence conducted at the University of Wisconsin, Madison, suggests that intact proteins made with GMP have important benefits for patients with PKU versus traditional synthetic amino acid based formulas. These benefits include: improved taste, increased satiety, lower dietary acid load and improved protein utilization (van Calcar, S.C., MacLeod, E.L., Gleason, S.T., Etzel, M.R., Clayton, M.K., Wolff, J.A. and Ney, D.M. “Improved Nutritional Management of Phenylketonuria by Using a Diet Containing Glycomacropeptide Compared with Amino Acids.” The American Journal of Clinical Nutrition. 89:1068-1077, 2009; MacLeod E., Clayton M., van Calcar S., Ney D. “Breakfast with Glycomacropeptide Compared with Amino Acids Suppresses Plasma Ghrelin Levels in Individuals with Phenylketonuria.” Molecular Genetics and Metabolism. 2010: Vol. 100, Issue 4: 303-308).

Patient acceptance of metabolic medical food can be a challenge. A recently published study found that the overall acceptance of medical food with glytactin products was statistically higher than traditional synthetic amino acid based formulas (Clayton M., Levy H., Murali, S., Ney D., Rice, G. Rohr F., Stroup, B., “Glycomacropeptide for Nutritional Management of Phenylketonuria: a Randomized, Controlled, Crossover Trial.” The American Journal of Clinical Nutrition, 10.3945, 116.135293, 2016).

Glytactin RESTORE Powder contains 5g protein equivalents (PE) and Glytactin RESTORE Lite Powder contains 10g PE with 55% fewer calories than Glytactin RESTORE Powder per gram of PE. The formulation contains B vitamins and electrolytes, which are important for individuals with PKU that have an active lifestyle as they help to replenish electrolytes lost during activities. Glytactin RESTORE Powder comes in two all-natural, delicious berry and orange flavors. Glytactin RESTORE Lite Powder comes in an all-natural orange flavor. The stick-pack shape of the RESTORE Powder packets makes them easy to mix into a bottle of water or an on-the-go sports bottle. Glytactin Restore Powder is an ideal addition to any PKU diet program for use at school, sports or any time on-the-go convenience is desired.

“My son stays active playing soccer but struggles to take his PKU formula before practice because he gets an upset stomach after drinking his amino acid formula. In addition, the formula is difficult to measure and mix. The RESTORE Powder is an easy, quick option for him to both take his formula and stay hydrated at the same time,” says Linda K., a mom whose son has PKU.”

About Cambrooke Therapeutics – Founded in 2000, Cambrooke Therapeutics is a private equity-backed, Massachusetts-based therapeutic nutrition company and global provider of medical nutrition products for patients with serious unmet medical needs. The company works with physicians and researchers from around the world to develop, test and commercialize products that are focused on inborn errors of metabolism and intractable epilepsy. More information is available atwww.cambrooke.com.